CORE
MANNA
Advanced
Aquaceutical Elixir
The Holy Grail Of Science In Supplementation
CORE MANNA
Glyco-Immune Support
We've Cracked The Genetic Code & We're Aiming For The Sweet Spot
Core Manna is the Product of a decade's worth of research, this revolutionary solution unlocks the body’s code to protect against pathogens, allergies, inflammation, and more!
Our proprietary groundbreaking glycobiology based formulation provides your body with the exact fuel it needs to support the entire system! With its unique blend of ingredients, Core Manna helps the body protect and rebuild itself during times of stress and infection with results that are limitless.
We are exposed to millions of potential pathogens daily. Our body uses sugars, or glycans, to fight back. Our immune cells usually have no problem recognizing the sugars on our own cells as ‘self’, but when pathogens use decoys to look like healthy cells, it can be difficult for the body to know what’s real or not.
Pathogens use ‘glycan shields’ and can alter sugar chains on the cell surface to avoid recognition. These foreigners have developed mechanisms to allow them to invade human cells, which forces the body to attack itself and shift its attention away from the pathogen. This may lead to undesired responses and symptoms in which one’s body attacks healthy cells rather than the pathogen.
Core Manna restores proper function with immune system signaling by glycoengineering, bioencoding, re-educating, and communicating all of the necessary components we need to establish 'self' vs. 'nonself' again for proper pattern recognition.
It is the first supplement to bring together cutting-edge ingredients to bio sync the body's natural self-healing process. We believe in looking at the needs of the whole person and getting to the core of the matter - not just addressing symptoms or symptoms of symptoms.
How It Works
Health and nutrition are controlled by sugar molecules because the entire system is regulated by sugar chains. Glycoimmunology is the study of how specific types of sugar chains, or glycans, impact our immune system. The potential applications range from immune system development, autoimmunity, host-pathogen defense, and much, much more!
The diversity of these complex sugar chains that form on the cell surface exceeds that even of DNA, with up to 25,000 genes, RNA, with approximately 360,000 mRNA, as every known cell is covered in glycans. Also, their structures exceed by orders of magnitude the number of the proteins encoded by our genome, which can be up to 400,000 proteins.
Simply put, they are essential to life. Without them, we would surely perish. In fact, the loss of any component of these bonded sugar molecules can result in dire consequences and incompatibility with life itself.
This makes supplying our bodies with the right types of Glyconutrients quintessentially SUPREME in all things health.
These synergetic compounds are found to be critical in supporting the function of the immune system, leading to healthy cellular metabolism, anti-inflammatory benefits, and so much more.
Core Manna's proprietary formulation has a unique blend of ingredients that contain nutrients your body uses to rebuild – after years of neglect, damage, stress, and improper nutrition.
We're excited to share with you more information about the Glycoimmunology principles that make up our immune system.
Using a simple acronym, we’re able to remember how these protections work together to keep us healthy.
"Be Sweet, and put a GAG Order on Pathogen Hijacking".
Complimenting The Sugar Code
Glycosaminoglycans (GAGs) are negatively-charged polysaccharide (sugar) compounds. They are essentially sulfated polysaccharides that are abundant in Sea Algae and Deer Velvet Antlers, for example.
GAGs play a key role in cell signaling, which serves to modulate a vast amount of biochemical processes. Some of these processes include the regulation of cell growth and proliferation, promotion of cell adhesion, anticoagulation, and wound repair, among many more.
The presentation of these GAGs can dictate whether positive or negative regulation of immune response occurs. Subversion of GAGs is a pathogenic strategy shared by a wide variety of microbial pathogens, including viruses, bacteria, parasites, and fungi. Pathogens use GAGs at virtually every major portal of entry to promote their attachment and invasion of host cells, movement from one cell to another, and to protect themselves from immune attack. Pathogens co-opt fundamental activities of GAGs to accomplish these tasks.
Glycosaminoglycans are used in the body as a lubricant for joints, for supporting connective tissues such as cartilage and tendons, and may even help assist with weight loss. Common GAGs include glucosamine, chondroitin sulfate, and hyaluronic acid.
Core Manna provides essential glycosaminoglycans (GAGs) thereby restoring the balance and harmony of cells.
Enhanced Bioavailability
Core Manna utilizes the latest in cutting edge technology to increase maximum absorption and bioavailability using the science of sweets. We've developed a proprietary Smart Carbon Oligosaccharide Nanoparticle Delivery System (SCONDS™).
At some point in time you may have encountered the belief that supplemental ingredients are too difficult for the body to absorb, and therefore of little use. And to be fair, there is some truth there; nutrients do have to be absorbed in order to be useful. To make natural compounds of any type more effective and consistent, they may require an extra boost. That’s where special plant-based oligosaccharides come in. Oligosaccharides are a type of carbohydrate chain made up of three to 10 simple sugars, which are also known as monosaccharides.
Specific plant-based oligosaccharides makes nutrients that may be difficult for the body to absorb and use into much more therapeutic and beneficial compounds that the body can assimilate much easier. Therefore, magnifying results exponentially!
Taking advantage of this sweet science improves the absorption of fat-soluble nutrients by enveloping them in an open-ended microscopic structure, sometimes described as “bucket shaped” or as a “truncated cone.” The exterior of this molecule is also water-soluble, yet can form complexes with many hydrophobic molecules, which allows it to escort ingredients through intestinal walls for better absorption, enhanced stability and bioavailability. In other words, mixing fat with water in a type of "programmed packaging".
These naturally occurring compounds encapsulate and preserve active compounds with their doughnut-like shape, which allows them to act as nanoparticle molecular containers that surround other compounds until they are ready to be released. This process also naturally increases the shelf life of raw material.
These glyconanocavities are stable core–shell nanoparticle encapsulated molecules which allow for the controlled release and direct cellular delivery of natural biomolecules over time, further increasing their beneficial effectiveness.
Benefits may include:
-
Nanoencapsulated aquaceutical delivery
-
Amplified absorption
-
Increased bioavailability
-
Heightened bioactivity
-
Enhanced molecular stability
-
Advanced particle distribution
-
Cutting-edge controlled release
Core Manna offers a unique advanced aquaceutical elixir that is designed to provide a wide range of health benefits for those looking to naturally improve their well-being. Our product combines natural herbal ingredients, with advanced nanotechnology to create a powerful, yet gentle elixir that can be used to enhance physical and mental health. We believe in the power of natural healing and are committed to providing the highest quality of care to our customers.
Core Manna Benefits
Core Manna supplies the system with a full spectrum of naturally occurring compounds providing your body with a multi-faceted approach to positively impact every system in the body. Core Manna’s proprietary blend is designed to address your nutritional needs and challenges by supplying vital nutrients that help regulate each body's system. This specialized formula makes it easier for you to live a healthy lifestyle, as well as enhance your mental, emotional, and physical performance.
Cellular Communication
If cells can't communicate they get divorced. Our cellular antenna, cilia, utilize glycoprotein-dependent adhesion mechanisms which enables cells to communicate and to interpret signals. Cellular communication is heavily relient on sugar chains.
Inflammation Resolution
Acute inflammation is the immune system's response to harmful pathogens, damaged cells, toxic compounds, and acts by removing injurious stimuli and initiating the healing process. Therefore, it is a defense mechanism that is vital to health. Chronic inflammation is deletarious and is characterized by marked changes in glycosylation.
Pathogen Protection
Host-pathogen interactions are fundamental to our understanding of infectious diseases. Pathogen protection is mediated through sugar chains presented on the cell surface. Glyconutrients play a vital role in preventing pathogen entry and act as a barrier of protection.
Enhanced Circulatory System Flow
The glycocalyx is a dense, gel-like meshwork made up uf sugar chains that surrounds the cell, constituting a physical barrier for any object to enter the cell. The endothelial glycocalyx plays an important role in vascular homeostasis with antithrombotic and anti-inflammatory functions.
Immune System Surveillance
Immune surveillance is a protective mechanism whereby the immune system recognizes and eliminates harmful pathogens. The majority of immune checkpoints are membrane glycoproteins. The cornerstone of a healthy immune system is the ability to distinguish “self” from “nonself” which is reliant on sugar chains.
Extracellular Matrix Mojo
The Extracellular Matrix (ECM) is a cohesive network of molecules linked to each other by glycoproteins that provide structural and biochemical support to surrounding cells. Glycosaminoglycans (GAGs) play a vital role within the Extracellular Matrix.
Nervous System Network Support
Glycosylation plays a critical role in the nervous system and regulates a number of Ion channels that control responses to environmental stimuli and voltage. Oligosaccharides are critical for brain and central nervous system function.
Circadian Clock Entrainment
External environmental cues, including light/dark cycles, food intake, stress, and exercise, provide important information for adjusting our interanl clock for the regulation of the sleep/wake cycles. Circadian clocks are regulated by protein glycosylation, glycogen metabolism, glucose transport and insulin sensitivity.
Heightened Brain Cognition
Glycolysis is essential for a variety of neural activities in the brain, including energy production, synaptic transmission, and redox homeostasis. In the brain, N-linked glycosylated proteins participate in a myriad of processes, from electrical gradients to neurotransmission.
Detoxification
Lysosomes are the garbage disposal units of our cells, roaming around digesting cellular waste with their specialized enzymes and recycling excess or worn-out cell parts. Lysosomes are also instrumental in the vital process of autophagy. Autophagy is the ultimate detox which removes and recycles unwanted or damaged molecules from your cells. Lysosomal proteins are heavily glycosylated.
Elevated Mitochondria Energy Production
The core interaction between mitochondrial metabolism, ATP production, and immune signaling has emerged as a central regulator of immune sensing. Mitochondrial functions, energy metabolism and protein glycosylation are interconnected processes.
RNA & DNA Synthesis
Nucleic acids, which are adenine, cytosine, guanine, thymine, and uracil, are essential to all known forms of life. They serve as the primary information-carrying molecules in cells and make up the genetic material. They create, encode, and then store information of every living cell of every life-form on Earth and transmit and express information to the next generation of each living organism.
Scientific Research
Formulated over many years of research to support all aspects of health and performance. Discover a new way to take your immune system to the next level! We are not just selling you a product here. Not only is Core Manna an amazing all-natural product, but it is also backed by the latest and most advanced research to help you live a healthier life, right now!
You can trace every known disease back to Glycoimmunology. Our Innate immune system controls the entire mainframe.
This is why Core Manna should be the foundation, or core, of anything else you do so that your body’s defenses are operating optimally allowing you to handle anything, anywhere, at any time.
Scientific Research
Glycoimmunology: ignore at your peril!
We are all glycoimmunologists. If you study a protein that is expressed on the surface of lymphocytes or dendritic cells or macrophages or any other mammalian cell, that protein is almost certainly glycosylated.
https://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.2009.00800.x
The Role of the Mannose-Binding Lectin in Innate Immunity
The innate immune system, which includes mannose-binding lectin (MBL), recognizes a broad range of molecular patterns on a broad range of infectious agents and is able to distinguish them from self.
https://academic.oup.com/cid/article/41/Supplement_7/S440/665932
Mannose-binding lectin and the balance between immune protection and complication
A pivotal link between the innate immune system and other functions is mannose-binding lectin (MBL), a pattern recognition molecule.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259613/
Glycosaminoglycans and infection
Subversion of GAGs is a pathogenic strategy shared by a wide variety of microbial pathogens, including viruses, bacteria, parasites, and fungi. Pathogens use GAGs at virtually every major portal of entry to promote their attachment and invasion of host cells, movement from one cell to another, and to protect themselves from immune attack. Pathogens co-opt fundamental activities of GAGs to accomplish these tasks.
Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy
Metabolic glycoengineering (MGE) is an easy but powerful technology for remodeling the structure of glycan. MGE provides us an opportunity to reshape the microenvironment and evoke desired cellular responses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940976/